OUR RESEARCH OBJECTIVES

OBJECTIVE 1

Generate a mechanistic understanding of renal aging from PM2.5 exposure studies in an environmentally controlled whole body exposure system.

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OBJECTIVE 2

Analyze ultrastructural morphology, chemical and elemental composition and traceability of PM2.5 components in air, blood, kidneys, and urine from mice, in collaboration with the institute of Astronomy, Geophysics and Atmospheric sciences from the University of São Paulo and the Dutch independent research organization TNO.

OBJECTIVE 3

Construct a multi-omics molecular signature (MOMS) of cumulative PM2.5 exposure in mice

OBJECTIVE 4

Investigate the enrichment of the MOMS in observational cohorts from Elsa-Brazil (São Paulo) and Lifelines DEEP (Groningen), related them to surrogate measures of PM2.5 exposure and validate the association with renal outcomes.